NOT KNOWN FACTS ABOUT NSI-189 PHOSPHATE

Employing VIII–X as being the lead compounds, we created and synthesized fourteen new derivatives with hopes for their greater solubility in aqueous alternatives (of lessen lipophilicity when compared to VIII–X).In the third path, ester 3 was hydrolyzed in alkaline conditions to acid 3b, And eventually this spinoff was converted to an amide 3c